Oleoyl ethanolamide CAS NO.111-58-0

Product introduction

 OEA is derived from the omega-9 monounsaturated fatty acid oleic acid. It is considered an endocannabinoid-like lipid, a receptor activated by peroxisome proliferator alpha (PPAR-alpha) that interacts with and mediates anti-inflammatory processes. The bioactive lipid amide OEA is synthesized in the gastrointestinal tract and is associated with multiple unique homeostatic properties, including anti-inflammatory activity, immune response, stimulation of lipolysis, and fatty acid oxidation. Furthermore, the fatty acid ethanolamide is a lipid mediator that regulates a large number of physiological functions. As a biologically active lipid mediator, oleoylethanolamide (OEA) is a potent agonist of peroxisome proliferator-activated receptor-α (PPAR-α) and can regulate the increased expression of fatty acid transferase CD36 , thereby regulating eating behavior. In addition, OEA is an endogenous fatty acid ethanolamine produced in the intestinal mucosa.  OEA anorexigenic signaling may be an essential element of the physiological and metabolic systems that regulate dietary fat intake and obesity. Ingestion of oleic acid, and the resulting OEA that confers anorexic characteristics, depends on CD36, PPAR-α, intestinal fat sensory receptors, histamine, oxytocin, and dopamine; leading to increased fat oxidation and energy expenditure, thereby producing a feeling of satiety and increases feeding latency; any disruption in these systems halts or inhibits fat-induced satiety.

Product name: Oleoyl ethanolamide

Other name:N-oleoyl ethanolamine;N-(2-hydroxyethyl)-,(Z)-9-Octadecenamide

CAS: 111-58-0

Formula Molecular: C20H39NO2

Molecular Weight: 325.53

Assay: 85%

Appearance:White to off-white powder

Package:25kg/drum

Uses: Oleoyl ethanolamide is recommended for use as a dietary supplement ingredient.

Application

 Oleoylethanolamide is a natural ethanolamide lipid used as a dietary planning and body weight regulator in a variety of vertebrate species. It is a metabolite of oleic acid formed in the human small intestine. Oleylethanolamide (OEA) is a molecule that regulates lipid metabolism and energy homeostasis. It sticks to PPAR Alpha receptors and helps control four factors: hunger, body fat, cholesterol and weight. PPAR Alpha represents peroxide proliferator-activated receptor alpha, and the bioactive lipid amide oleoylethanolamide (OEA) has a variety of unique homeostatic properties, including anti-inflammatory activity, immune response modulation, and antioxidant effects.